Product Name: LDL receptor antibody
Applications:
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification: Purified by affinity chromatography
Full Name: low density lipoprotein receptor
Background: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia.
Synonyms: FH, FHC, LDLCQ2
Cellular Localization:
CAS NO: 22254-24-6
Product: BIBF 1120 (esylate)
Host: Chicken
Clonality: Polyclonal
Isotype: IgY
Immunogen: Immunogen Sequence: GI # 4504975, sequence 29-205 Recombinant low density lipoprotein receptor
Antigen Species: Human
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: PBS, 0.02% sodium azide
Storage Instruction: Keep as concentrated solution. For short-term storage, store at 4° C (up to 10 days). For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20418503?dopt=Abstract
