Product Name: LDL Receptor antibody [11A2]
Applications: ELISA, FACS, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification: The IgG fraction of culture supernatant was purified by Protein G affinity chromatography
Full Name: low density lipoprotein receptor
Background: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
Synonyms: low density lipoprotein receptor Antibody , LDLR Antibody , FHC Antibody , LDLCQ2 Antibody , FH Antibody
Cellular Localization:
CAS NO: 89-57-6
Product: Emapunil
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen: Recombinant Human LDL Receptor.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: PBS
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody recognizes human LDL Receptor by ELISA and Western Blott.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20466038?dopt=Abstract
