Product Name: LDL Receptor antibody [IgG-C7]
Applications: FACS, IM, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 0.05 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified IgG
Full Name: low density lipoprotein receptor
Background: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
Synonyms: FH Antibody , LDLR Antibody , LDLCQ2 Antibody , FHC Antibody
Cellular Localization: Found distributed from the plasma membrane to intracellular compartments.
CAS NO: 1172118-03-4
Product: SSR128129E (free acid)
Host: Mouse
Clonality: Monoclonal
Isotype: IgG2b
Immunogen: Purified bovine adrenal cortex LDL receptor.
Antigen Species: Bovine
Species Reactivity: Human, Bovine
Conjugation: Unconjugated
Storage Buffer: PBS pH 7.4, 0.5mg/ml BSA
Storage Instruction: Keep as concentrated solution. For short-term storage, store at 4° C (up to 10 days). For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: Recognizes an epitope in the region of repeat #1 of the ligand binding region. Addition of 15 nM antibodyresults in inhibition of half-maximal LDL-binding.(1) Recognizes human and cow. Does not react with rat,mouse, hamster (Chinese hamster ovary cells), dog and rabbit.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/19845480?dopt=Abstract
