Product Name: LEF1 antibody [1C3.1D10]
Applications: WB
Predicted Target Size:
Positive Controls:
Form Supplied:
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Protein G purified
Full Name: lymphoid enhancer-binding factor 1
Background: Lymphoid enhancer factor, LEF1, is a transcription factor of the High Mobility Group of DNA binding proteins. It is one member of a family of four proteins referred to as LEF/TCF transcription factors (LEF1, TCF1, TCF3 and TCF4). These factors play crucial roles in WNT/Wingless signaling, a signal transduction cascade that directs cell differentiation. Aberrant activation of the WNT/Wingless pathway is also a root cause in the genesis of certain cancers such as colon cancer, melanoma and breast cancer.
Synonyms: DKFZp586H0919, FLJ46390, TCF1ALPHA
Cellular Localization: Nuclear
CAS NO: 13292-46-1
Product: Marimastat
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen: Synthetic peptide: TGIPHPAIVT PQVKQEHPHT DSDLMHVKPQ HEQRKEQEPK RP, corresponding to amino acids 256-297 of Human LEF1.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: 0.01M PBS. pH 7.5 containing 0.08% Sodium Azide
Storage Instruction: Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: Recognizes all human LEF1 isoforms using Western blotting. The antibody does not cross-react with TCF1 or TCF4.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/19895853?dopt=Abstract
