Product Name: LEF1 antibody [3A12]
Applications: WB
Predicted Target Size:
Positive Controls:
Form Supplied:
Concentration: ~1 mg/ml
Purification: Purified immunoglobulin
Full Name: lymphoid enhancer binding factor 1
Background: Lymphoid enhancer factor, LEF1, is a transcription factor of the High Mobility Group of DNA binding proteins. It is one member of a family of four proteins referred to as LEF/TCF transcription factors (LEF1, TCF1, TCF3 and TCF4). These factors play crucial roles in WNT/Wingless signaling, a signal transduction cascade that directs cell differentiation. Aberrant activation of the WNT/Wingless pathway is also a root cause in the genesis of certain cancers such as colon cancer, melanoma and breast cancer.
Synonyms: DKFZp586H0919, FLJ46390, TCF1ALPHA
Cellular Localization:
CAS NO: 2207-75-2
Product: RGB-286638
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen: synthetic peptide corresponding to amino acids 236-242 (DTSMSRF) of human LEF-1.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: 0.01M PBS pH7.5, 0.08% sodium azide
Storage Instruction: Keep as concentrated solution. For short-term storage, store at 4° C (up to 10 days). For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/19513116?dopt=Abstract
