Product Name: LIMP II antibody
Applications: ELISA, IHC-P, WB
Predicted Target Size:
Positive Controls: Blocking Peptide:Cat.No. GTX85031-PEP – LIMP2 PeptideLysates:Cat. No. GTX15370 – Human Skeletal Muscle Tissue Lysate
Form Supplied: Liquid
Concentration:
Purification: Affinity chromatography purified via peptide column
Full Name: scavenger receptor class B, member 2
Background: The lysosomal integral membrane protein 2 (LIMP2) is a heavily glycosylated type III transmembrane protein, the majority of which exists in the lumen of the lysosome and a cytoplasmic domain of approximately 20 amino acids. A deficiency of LIMP2 in mice causes uretic pelvic junction obstruction, deafness, and peripheral neuropathy associated with impaired vesicular trafficking and distribution of apically expressed proteins. More recently, LIMP2 was shown to act as a receptor to bind b-glucocerebrosidase, the enzyme defective in Gaucher disease, a lysosomal storage disorder. LIMP2-deficient mice showed missorted as well as secreted b-glucocerebrosidase, suggesting that LIMP2 also functions as the mannose-6-phosphate-independent trafficking receptor. Despite its predicted molecular weight, LIMP2 runs at approximately 80 – 85 kDa in SDS-PAGE.
Synonyms: CD36L2, Lysosomal integral membrane protein 2, SR-B2, SRB2, Scavenger receptor class B member2, Lysosomal integral membrane protein2, SCARB2, LIMP2, Scavenger receptor class B member 2, SR B2
Cellular Localization:
CAS NO: 128196-01-0
Product: AMG 837
Host: Rabbit
Clonality: Polyclonal
Isotype:
Immunogen:
Antigen Species:
Species Reactivity: Human, Mouse
Conjugation: Unconjugated
Storage Buffer: Antibody is supplied in PBS containing 0.02% sodium azide
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody is specific for LIMP2
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/26631871?dopt=Abstract
