Product Name: LMAN1 antibody
Applications: WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification: Purified by affinity chromatography
Full Name: lectin, mannose binding 1
Background: Mannose-specific lectin. May recognize sugar residues of glycoproteins. glycolipids. or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins. lipids. or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi. presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning. the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency. a rare. autosomal recessive disorder in which both coagulation factors V and VIII are diminished.
Synonyms: ERGIC-53, ERGIC53, F5F8D, FMFD1, MCFD1, MR60, gp58, ERGIC 53
Cellular Localization:
CAS NO: 128-13-2
Product: LY451395
Host: Chicken
Clonality: Polyclonal
Isotype: IgY
Immunogen: Immunogen Sequence: GI # 5031873, sequence 270-470 Recombinant lectin, mannose-binding, 1
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: PBS, 0.02% sodium azide
Storage Instruction: Keep as concentrated solution. For short-term storage, store at 4° C (up to 10 days). For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/15258154?dopt=Abstract
