Product Name: DNAL1 antibody
Applications: ELISA, ICC/IF, WB
Predicted Target Size:
Positive Controls: Blocking Peptide:Cat.No. GTX85387-PEP – DNAL1 PeptideLysates:Cat. No. GTX27901 – 3T3 (NIH) Cell Lysate
Form Supplied: Liquid
Concentration:
Purification: Affinity chromatography purified via peptide column
Full Name: dynein, axonemal, light chain 1
Background: DNAL1 was identified as a potential candidate gene for primary ciliary dyskinesia (PCD), a genetically heterologous disorder characterized by chronic infections of the upper and lower airways that often leads to permanent lung damage, randomization of left/right body symmetry, and reduced fertility. DNAL1 is reported to be expressed solely in tissues carrying motile cilia for flagella and interacts with DNAH5, a protein that when mutated has been shown to result in PCD. It has been suggested that DNAL1 serves a regulatory function for DNAH5 activity in outer dynein arms of sperm flagella, respiratory cilia, and ependymal cilia. DNAL1 has also been recently identified as an HIV dependency factor (HDF), suggesting that DNAL1 may be an important drug target in HIV treatment. At least two isoforms of DNAL1 are known to exist.
Synonyms: DNAL1, Dynein axonemal light chain1, Dynein axonemal light chain 1
Cellular Localization:
CAS NO: 118292-40-3
Product: LY 344864
Host: Rabbit
Clonality: Polyclonal
Isotype:
Immunogen:
Antigen Species:
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: PBS containing 0.02% sodium azide
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody is specific for DNAL1
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22562112?dopt=Abstract
