Product Name: DNA-PKcs antibody
Applications: WB
Predicted Target Size: 450 (note)
Positive Controls:
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Full Name: protein kinase, DNA-activated, catalytic polypeptide
Background: The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties
Synonyms: DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350, PRKDC, p460, hyper-radiosensitivity of murine scid mutation, complementing 1, DNA-PK catalytic subunit, DNA-dependent protein kinase catalytic subunit, protein kinase, DNA-activated, catalytic polypeptide
Cellular Localization:
CAS NO: 198481-33-3
Product: M344
Host: Rabbit
Clonality: Polyclonal
Isotype:
Immunogen: Peptide sequence around aa.2607~2611 (V-E-T-Q-A) derived from Human DNA-PK.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/23236175?dopt=Abstract
