Product Name: DNMT1 antibody, Internal
Applications: IHC-P, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Full Name: DNA (cytosine-5-)-methyltransferase 1
Background: Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.
Synonyms: FLJ16293, CXXC9, DNA methyltransferase 1, DNA methyltransferase1, DNA (cytosine5)methyltransferase1, DNMT, DNMT1, DNA (cytosine-5-)-methyltransferase 1, DNA (cytosine5)methyltransferase 1, MCMT, MGC104992, AIM
Cellular Localization:
CAS NO: 1246086-78-1
Product: Daminozide
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Immunogen: C-RFESPPKTQPTEDN
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Storage Instruction: Aliquot and store at -20°C. Minimize freezing and thawing.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody is specific for DNMT1.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21908788?dopt=Abstract
