Product Name: DNMT3B antibody
Applications: WB
Predicted Target Size: 97 kDa (note) (5)
Positive Controls: Recombinant DNMT3B protein
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified by antigen-affinity chromatography.
Full Name: DNA methyltransferase 3B
Background: Required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.
Synonyms: DNA (cytosine-5)-methyltransferase 3B antibody, DNA MTase MmuIIIB antibody, m.MmuIIIB antibody, DNA methyltransferase MmuIIIB antibody, MGC124407 antibody, Dnmt3b antibody, DNA methyltransferase 3B antibody
Cellular Localization: Nucleus
CAS NO: 377727-87-2
Product: Daunorubicin (Hydrochloride)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of mouse DNMT3B. The exact sequence is proprietary.
Antigen Species: Mouse
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: 1XPBS, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21347380?dopt=Abstract
