Product Name: DNMT3L antibody [S117-9]
Applications: ICC/IF, IP, WB
Predicted Target Size: 45kDa (note)
Positive Controls:
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Protein G Purified
Full Name: DNA (cytosine-5-)-methyltransferase 3-like
Background: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases. This protein is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, this protein does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternative splicing results in two transcript variants. An additional splice variant has been described but its biological validity has not been determined. [provided by RefSeq]
Synonyms: DNA (cytosine5)methyltransferease3like, DNA (cytosine-5-)-methyltransferease 3-like, MGC1090, DNMT3L
Cellular Localization:
CAS NO: 193001-14-8
Product: Fulvestrant
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen: Fusion protein amino acids 1-387 of human DNMT3L, accession number BAA95556
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: PBS pH7.4, 50% glycerol
Storage Instruction: Aliquot and store at -20 C. Avoid repeated freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: No cross-reactivity against DNMT3a or DNMT3B.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21623382?dopt=Abstract
