Product Name: DNase II antibody
Applications: IHC-P, WB
Predicted Target Size:
Positive Controls: Human spleen tissue lysate
Form Supplied: Liquid
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Affinity purified with antigen
Full Name: deoxyribonuclease II, lysosomal
Background: Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins including AIF and Acinus (1). DNase II causes both chromatin condensation and DNA fragmentation (1). The genes encoding human (2-4), porcine (4), and murine (5) DNase II have been cloned. The DNase II gene encodes a 40 kDa proenzyme. The mature enzyme consists of two non-identical subunits, the 32 kDa (a) and 12kDa (b) chains, generated by proteolytic processing. Overexpression of DNase II induces chromatin condensation (3). DNase II is ubiquitously expressed in human tissues.
Synonyms: 1777, DNL, 126350, DNase II, DNASE2A, DNASE2, O00115, DNL2
Cellular Localization:
CAS NO: 95167-41-2
Product: Edoxaban (tosylate monohydrate)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Synthetic peptide – amino acids 347 – 360 of human DNase II
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Phosphate-buffered saline, pH 7.4 containing 0.02% sodium azide
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: Specific for the 32 kD alpha chain; does not recognise the 12 kD beta chain
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22292082?dopt=Abstract
