Product Name: DNase I antibody
Applications: WB
Predicted Target Size:
Positive Controls: bovine pancreatic DNase I
Form Supplied: Liquid
Concentration: ~1 mg/ml
Purification: IgG fraction
Full Name: deoxyribonuclease I
Background: Deoxyribonuclease I (DNase I) is a Ca2+ and Mg2+ dependent endonuclease. DNase I is synthesized in the pancreas and stored in zymogen granules. It has been used to reduce the viscosity of cystic fibrosis sputum. A DNase I-like enzyme appears to catalyze the degradation of chromatin to oligo-and mononucleosomes during apoptosis. A recent study has demonstrated an endonuclease with activity and antigenicity indistinguishable from DNase I in thymocytes, cells susceptible to apoptosis. Deoxyribonuclease I (DNase I) is an endonuclease that hydrolyzes double-stranded or single-stranded DNA preferentially at sites adjacent to pyrimidine nucleotides. The product of hydrolysis is a complex mixture of 5 phosphate mononucleotides and oligonucleotides. In the presence of magnesium ion, DNase I attacks each strand of DNA independently and the cleavage sites are random.
Synonyms: DNASE1, DNase I, 282217
Cellular Localization:
CAS NO: 405060-95-9
Product: Naloxone (hydrochloride)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: bovine pancreatic deoxyribonuclease I (DNase I).
Antigen Species: Bovine
Species Reactivity: Bovine
Conjugation: Unconjugated
Storage Buffer: PBS pH7.2, 0.01% sodium azide
Storage Instruction: Keep as concentrated solution. For short-term storage, store at 4° C (up to 10 days). For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22499765?dopt=Abstract
