Product Name: DPF1 antibody, C-term
Applications: WB
Predicted Target Size:
Positive Controls: The peptide used to product this antibody is available for purchase (Catalog Number:GTX89872-PEP).
Form Supplied: Liquid
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Full Name: D4, zinc and double PHD fingers family 1
Background: May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
Synonyms: neurod4 homo, Neurod4 (rat) homolog, D4, zinc and double PHD fingers, family1, OTTHUMP00000211615, D4, zinc and double PHD fingers family1, neuro-d4, MGC150429, neuro-d4 homolog, Neuro-d4 (rat) homolog, NEUD4, D4, zinc and double PHD fingers, family 1, Neurod4 / DPF1, neurod4 homolog, neurod4, D4, zinc and double PHD fingers family 1, BAF45b, MGC150428, neuro d4, neuro d4 homolog, Neuro d4 (rat) homolog
Cellular Localization:
CAS NO: 167354-41-8
Product: PF-5274857
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Immunogen: C-HLKEKASAYITLT
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Storage Instruction: Aliquot and store at -20°C. Minimize freezing and thawing.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody is specific for DPF1.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/18256199?dopt=Abstract
