Product Name: DR4 antibody
Applications: ELISA, ICC/IF, IHC-P, WB
Predicted Target Size:
Positive Controls: HeLa whole cell lysate A 57 kDa band should be detected.
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: IgG fraction
Full Name: tumor necrosis factor receptor superfamily, member 10a
Background: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1and Fas. A novel cell death receptor was recently identified and designated DR4 (for death receptor4)(1). The ligand for this novel death receptor has been identified and termed TRAIL (2,3), which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1)(4). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4mediates apoptosis and NF-kB activation in many tissues and cells.
Synonyms: MGC9365, TRAILR1, APO2, TNFRSF10A, 603611, 8797, O00220, DR4, TRAILR-1, CD261, TRAILR 1
Cellular Localization: Cell Membrane
CAS NO: 49562-28-9
Product: (S)-Tedizolid
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Synthetic peptide, corresponding to amino acids 427-445 of Human DR4.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: PBS with 0.02% sodium azide
Storage Instruction: Keep as concentrated solution, aliquot and store at 4°C.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: Does not cross react with DR5.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/17371845?dopt=Abstract
