Product Name: DR4 antibody [32A1380]
Applications: WB
Predicted Target Size:
Positive Controls: Daudi whole-cell extract
Form Supplied: Liquid
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Protein G purified
Full Name: tumor necrosis factor receptor superfamily, member 10a
Background: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified and designated DR4 (for death receptor 4). The ligand for this novel death receptor has been identified and termed TRAIL, which is a new member in the TNF family. DR4 is also called TRAIL receptor 1(TRAIL R1). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF kB activation in many tissues and cells.
Synonyms: MGC9365, TRAILR1, APO2, TNFRSF10A, 603611, 8797, O00220, DR4, TRAILR-1, TRAILR 1
Cellular Localization: Cell Membrane
CAS NO: 336113-53-2
Product: Olprinone
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen: Synthetic peptide, corresponding to amino acids 1 – 20 of Human DR4.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Preservative: 0.02% Sodium Azide; Constituents: PBS
Storage Instruction: Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/16987990?dopt=Abstract
