Product Name: DR4 antibody [DR-4-02] (FITC)
Applications: FACS, ICC/IF, IP, Functional Assay
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification:
Full Name: tumor necrosis factor receptor superfamily, member 10a
Background: TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues.Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family – TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).Entrez Gene: 8p21
Synonyms: APO2, DR4, MGC9365, TRAILR-1, TRAILR1
Cellular Localization:
CAS NO: 79794-75-5
Product: Impurity C of Alfacalcidol
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen: Fusion protein containing the extracellular part of DR4 and the constant part of the heavy chain of the human IgG1.
Antigen Species: Human
Species Reactivity: Human
Conjugation: FITC
Storage Buffer: The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
Storage Instruction: Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.Do not use after expiration date stamped on vial label. Short-term exposure to room temperature should not affect the quality of the reagent. However, if reagent is sto
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: The antibody DR-4-02 recognizes TRAIL-R1 (DR4), a human death receptor 4 (468 amino acids) expressed in most human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumour-derived cell lines.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/17695254?dopt=Abstract
