Product Name: DR6 antibody
Applications: WB
Predicted Target Size:
Positive Controls: HeLa whole-cell extract
Form Supplied: Liquid
Concentration: 0.2 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Protein A purified
Full Name: tumor necrosis factor receptor superfamily, member 21
Background: Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor 6. Like TNFR1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed inhuman tissues and cell lines. The ligand for DR6 hasnot been identified.
Synonyms: 27242, BM-018, O75509, 605732, TNFRSF21, MGC31965, BM018, DR6, BM 018
Cellular Localization: Cell Membrane
CAS NO: 869113-09-7
Product: ALW-II-41-27
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG2
Immunogen: Synthetic peptide, corresponding to amino acids 371 – 655 of Human DR6.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Preservative: 0.02% Sodium Azide; Constituents: PBS
Storage Instruction: Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/16608873?dopt=Abstract
