Product Name: DR6 antibody [DR-6-04-EC] (DyLight 649)
Applications: FACS, ICC/IF, IP
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification:
Full Name:
Background: CD358 / DR6 (Death Receptor-6) is a type I transmembrane protein of the TNF receptor superfamily, expressed in most human tissues and able of inducing apoptosis through its cytoplasmic death domain. Unlike TNFR1 and Fas, DR6 induces apoptosis independently of FADD adaptor. In immune system, DR6 serves as an important regulator for CD4+ T cell proliferation and Th differentiation, and provides also a regulatory mechanism for B cell activation and humoral immune responses. Entrez Gene: 6p21.1-p12.2
Synonyms: DR6
Cellular Localization:
CAS NO: 758683-21-5
Product: Ziprasidone (hydrochloride monohydrate)
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen: A fusion protein representing amino acids 42-335 (extracellular part) of human DR6 linked to the Fc portion of human IgG1 was used as an immunogen.
Antigen Species: Human
Species Reactivity: Human
Conjugation: DyLight649
Storage Buffer: The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
Storage Instruction: Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.Do not use after expiration date stamped on vial label. Short-term exposure to room temperature should not affect the quality of the reagent. However, if reagent is sto
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: The antibody DR-6-04-EC recognizes human DR6 (Death receptor-6), a type I transmembrane protein containing cytoplasmic death domain, widely expressed in most human tissues and cell lines.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/16496354?dopt=Abstract
