Product Name: DR6 antibody [Luke-1]
Applications: FACS
Predicted Target Size:
Positive Controls:
Form Supplied:
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: >95% by SDS-PAGE
Full Name: tumor necrosis factor receptor superfamily, member 21
Background: Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor 6. Like TNFR1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed inhuman tissues and cell lines. The ligand for DR6 hasnot been identified.
Synonyms: BM-018, 27242, O75509, 605732, TNFRSF21, MGC31965, BM018, DR6, BM 018
Cellular Localization: Type I membrane protein.
CAS NO: 1020315-31-4
Product: NG 52
Host: Rat
Clonality: Monoclonal
Isotype: IgG2a
Immunogen: Recombinant fusion protein DR6:Fc, corresponding to amino acids 42-335 of Human DR6.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Preservative: 0.02% Sodium Azide. Constituents: PBS.
Storage Instruction: Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/16971524?dopt=Abstract
