Product Name: DRAM antibody
Applications: ELISA, ICC/IF, IHC-P, WB
Predicted Target Size:
Positive Controls: Blocking Peptide:
Form Supplied: Liquid
Concentration:
Purification: Affinity chromatography purified via peptide column
Full Name: DNA-damage regulated autophagy modulator 1
Background: Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.
Synonyms: Damage-regulated autophagy modulator, DRAM, Damageregulated autophagy modulator
Cellular Localization:
CAS NO: 85650-56-2
Product: CB30865
Host: Rabbit
Clonality: Polyclonal
Isotype:
Immunogen:
Antigen Species: Human
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: PBS containing 0.02% sodium azide
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody is specific for DRAM C-Terminus
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/15983403?dopt=Abstract
