Product Name: DSCAM antibody, Internal
Applications: WB
Predicted Target Size:
Positive Controls: The peptide used to product this antibody is available for purchase (Catalog Number:GTX89275-PEP).
Form Supplied: Liquid
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Full Name: Down syndrome cell adhesion molecule
Background: Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Enhances netrin-induced phosphorylation of PAK1 and FYN. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38.
Synonyms: human CHD252 down syndrome cell adhesion molecule, CHD242, CHD252, Down syndrome cell adhesion molecule, DSCAM, CHD2-52, CHD2-42, human CHD2-52 down syndrome cell adhesion molecule
Cellular Localization: Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons.
CAS NO: 331963-29-2
Product: SCH900776 (S-isomer)
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Immunogen: C-DSWDSAQRTKDVSPQ
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Storage Instruction: Aliquot and store at -20°C. Minimize freezing and thawing.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody is specific for DSCAM.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/26780186?dopt=Abstract
