Product Name: DUSP10 antibody
Applications: WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration)
Purification: IgG fraction
Full Name: dual specificity phosphatase 10
Background: Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq]
Synonyms: Q9Y6W6, DUSP10, 608867, MKP-5, MKP5, 11221, MKP 5
Cellular Localization:
CAS NO: 867331-82-6
Product: kb NB 142-70
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Immunogen: Peptide with sequence RILTPKLMGVETVV, from C Terminus of the protein sequence according to NP_009138; NP_653329; NP_653330
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Tris saline, 0.02% Na azide, pH7.3 with 0.5% BSA
Storage Instruction: Upon receipt – Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody is expected to recognise all three human isoforms of this protein.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27554486?dopt=Abstract
