Product Name: DUSP1 antibody, C-term
Applications: IHC-P, WB
Predicted Target Size: 39.3 (note)
Positive Controls: The peptide used to product this antibody is available for purchase (Catalog Number:GTX47608-PEP).
Form Supplied: Liquid
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Full Name: dual specificity phosphatase 1
Background: The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq]
Synonyms: dual specificity phosphatase 1, dual specificity phosphatase1, serine/threonine specific protein phosphatase, HVH1, MKP1, MKP-1, PTPN10, CL100, DUSP1, MKP 1
Cellular Localization:
CAS NO: 1018069-81-2
Product: Genipin
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Immunogen: SYLQSPITTSPSC
Antigen Species: Human
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Storage Instruction: Aliquot and store at -20°C. Minimize freezing and thawing.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody is specific for DUSP1.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/26739565?dopt=Abstract
