Product Name: DUSP1 (phospho Ser296/Ser318) antibody
Applications: IHC, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Antigen affinity purification
Full Name: dual specificity phosphatase 1
Background: The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq, Jul 2008]
Synonyms: MKP 1/2 (phospho Ser296/Ser318) Phospho Antibody, dual specificity phosphatase 1 Antibody, MKP 1/2 (phospho Ser296/Ser318) (phospho ) Antibody, HVH1 Antibody, Phospho MKP 1/2 (phospho Ser296/Ser318) Antibody, MKP 1/2 (phospho Ser296/Ser318) (p) Antibody
Cellular Localization:
CAS NO: 934353-76-1
Product: B-Raf inhibitor
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: A synthesized peptide derived from human DUSP1 around the phosphorylation site of Ser296/Ser318
Antigen Species: Human
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/26831103?dopt=Abstract
