Product Name: DUSP4 antibody
Applications: ELISA, IHC, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Full Name: dual specificity phosphatase 4
Background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008]
Synonyms: MKP2 Antibody , dual specificity phosphatase 4 Antibody , TYP Antibody , HVH2 Antibody
Cellular Localization:
CAS NO: 16676-29-2
Product: KN-93
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Synthesized peptide derived from the Internal region of human MKP-2 at AA range: 50-130.
Antigen Species: Human
Species Reactivity: Human, Mouse, Monkey, Rat
Conjugation: Unconjugated
Storage Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instruction: Store at -20°C. Avoid repeated freeze/thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: MKP-2 Polyclonal Antibody detects endogenous levels of MKP-2 protein.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/26715742?dopt=Abstract
