Product Name: DYRK1A antibody
Applications: WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification: Affinity purification
Full Name: dual specificity tyrosine phosphorylation regulated kinase 1A
Background: This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5 UTR or in the 3 coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]
Synonyms: MNB Antibody , dual specificity tyrosine phosphorylation regulated kinase 1A Antibody , MNBH Antibody , DYRK Antibody , HP86 Antibody , DYRK1 Antibody , MRD7 Antibody
Cellular Localization:
CAS NO: 1217448-46-8
Product: Salubrinal
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Recombinant protein of human DYRK1A
Antigen Species: Human
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Instruction: Store at -20℃. Avoid freeze / thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/26653852?dopt=Abstract
