Product Name: E2F3 antibody [N2C3]
Applications: WB
Predicted Target Size: 49 kDa (note) (2)
Positive Controls: 293T
Form Supplied: Liquid
Concentration: 0.28 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified by antigen-affinity chromatography.
Full Name: E2F transcription factor 3
Background: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. [provided by RefSeq]
Synonyms: DKFZp686C18211 antibody, E2F-3 antibody, KIAA0075 antibody, MGC104598 antibody, E2F3 antibody, transcription factor E2F3 antibody, E2F transcription factor 3 antibody
Cellular Localization:
CAS NO: 95058-81-4
Product: EVP-6124
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Recombinant protein encompassing a sequence within the center region of human E2F3. The exact sequence is proprietary.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: 1XPBS, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: Knockdown/Knockout validation was supported by customer review data.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/25470045?dopt=Abstract
