Product Name: EGFR antibody [199.12]
Applications: ELISA, FACS, ICC/IF, IP, Neut, WB, ChIP assay
Predicted Target Size:
Positive Controls: A431 cells.
Form Supplied: Liquid
Concentration: 0.2 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Protein A purified
Full Name: epidermal growth factor receptor
Background: EGFR is the prototype member of the type 1 receptor tyrosine kinases. EGFR is encoded by the cellular oncogene c-erbB-1. EGFR has an extracellular ligand binding domain, a single transmembrane region, and cytoplasmic domain which is composed of a tyrosine kinase domain and a carboxy terminal domain. The carboxy terminal domain contains at least four tyrosine autophosphorylation sites. EGFR over-expression in tumors indicates poor prognosis. EGFR over-expression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, and stomach, and in squamous cell carcinoma.
Synonyms: ERBB1, 131550, 1956, EGFR, ERBB, mENA, P00533
Cellular Localization: Cell Membrane and Secreted
CAS NO: 144060-53-7
Product: Tedizolid
Host: Mouse
Clonality: Monoclonal
Isotype: IgG2a
Immunogen: The extracellular domain of human recombinant EGFR protein, purified.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Preservative: 0.09% Sodium Azide; Constituents: 0.2% BSA, 10mM PBS. pH 7.4
Storage Instruction: Keep as concentrated solution, aliquot and store at 4°C.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody binds to the intact and vIII variant of EGFR. This antibody shows no cross reactivity with c-erbB-2, c-erbB-3, or c-erbB-4.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24349371?dopt=Abstract
