Product Name: EGFR antibody [Cocktail R19/48 (111.6 + 199.12 + F4 + 11E8)]
Applications: IP, WB
Predicted Target Size:
Positive Controls: A431 cells
Form Supplied:
Concentration: 0.2 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Protein A purified
Full Name: epidermal growth factor receptor
Background: EGFR is the prototype member of the type 1 receptor tyrosine kinases. EGFR is encoded by the cellular oncogene c-erbB-1. EGFR has an extracellular ligand binding domain, a single transmembrane region, and cytoplasmic domain which is composed of a tyrosine kinase domain and a carboxy terminal domain. The carboxy terminal domain contains at least four tyrosine autophosphorylation sites. EGFR over-expression in tumors indicates poor prognosis. EGFR over-expression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
Synonyms: ERBB1, 131550, 1956, EGFR, ERBB, mENA, P00533
Cellular Localization: Cell Membrane and Secreted
CAS NO: 134404-52-7
Product: MK-2894 (sodium salt)
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Immunogen: Purified extracellular and cytoplasmic domains of human recombinant EGFR protein.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Preservative: 0.09% Sodium Azide; Constituents: 0.2% BSA, 10mM PBS. pH 7.4
Storage Instruction: Store at 2 to 8ÂșC.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/23678122?dopt=Abstract
