Product Name: EGFR antibody [SP9] (ready-to-use)
Applications: FACS, IHC, IHC-P
Predicted Target Size:
Positive Controls: Placenta, Lung
Form Supplied: Liquid
Concentration: Ready-to-use
Purification:
Full Name: epidermal growth factor receptor
Background: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq]
Synonyms: EGFR, P00533, ERBB1, 131550, 1956, ERBB, mENA, HER1, PIG61
Cellular Localization: Cytoplasmic
CAS NO: 135729-61-2
Product: YK-4-279
Host: Rabbit
Clonality: Monoclonal
Isotype: IgG
Immunogen: A synthetic peptide from C-terminus of human EGFR protein.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: The buffer contains BSA and 0.05% sodium azide.
Storage Instruction: Keep as concentrated solution, aliquot and store at 4°C. Do not freeze.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody recognizes EGFR. EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, 02, 03, -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-alpha (TGF-alpha), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head, neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.This antibody crossreacts with Human.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24265806?dopt=Abstract
