Product Name: EGFR (phospho Tyr1068) antibody [Y38]
Applications: FACS, ICC/IF, IP, WB
Predicted Target Size: 170 (note)
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification: Cell Supernatant
Full Name: epidermal growth factor receptor
Background: Epidermal growth factor receptor (EGFR) is a 170 kDa transmembrane glycoprotein receptor tyrosine kinase that, activated by epidermal growth factor (EGF), affects cell growth and differentiation . Binding of EGF or TGF alpha to EGFR activates tyrosine kinase activity of the receptor . The carboxy terminal tyrosine residues on EGFR, Tyr 1068, Tyr 1148, and Tyr 1173, are the major sites of autophosphorylation, which occurs as a result of EGF binding . Once activated, EGFR phosphotyrosines Y-1068 and Y-1173 mediate the binding of Grb2 to the EGFR. Additionally, phosphotyrosine Y-1173 is a major binding site for SHC on the EGFR .
Synonyms: ERBB1, HER1, EGFR, ERBB, mENA, PIG61, EGFR (phospho Y1068), EGFR (phospho Tyr1068), EGFR (pY1068), EGFR (pTyr1068), EGFR phospho Y1068, EGFR phospho Tyr1068, Phospho EGFR (Y1068), Phospho EGFR (Tyr1068), Phospho EGFR (pY1068), Phospho EGFR (pTyr1068)
Cellular Localization:
CAS NO: 124431-80-7
Product: AIM-100
Host: Rabbit
Clonality: Monoclonal
Isotype: IgG
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Tyr1068 of human EGF receptor was used as immunogen.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage Instruction: Store at -20 °C. Stable for 12 months from date of receipt.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,488.
Specificity: The full-length EGFR includes the 24 aa signal peptide that is cleaved during EGFR maturation. The Tyr1068 of mature EGFR is equivalent to Tyr1092 of uncleaved EGFR.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/23530049?dopt=Abstract
