Product Name: EIF5A antibody [AT2E9]
Applications: ELISA, ICC/IF, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: By protein-G affinity chromatography
Full Name: eukaryotic translation initiation factor 5A
Background: EIF5A, previously known as EIF4D and IF-M2Ba, is a highly conserved 17-kDa protein that was originally characterized as a translation initiation factor, promoting the formation of the first peptide bond in mRNA translation in vitro. This is best positioned as a factor that controls the balance between cellular proliferation and death, depending upon the nature of cellular stress. Moreover, mutational analysis using human EIF5A to complement an EIF5A null strain of S. cerevisiae supports a role for EIF5A in protein synthesis. The activity of EIF5A is modulated by the covalent addition of the spermidine derivative hypusine to lysine residue 50.
Synonyms: Eukaryotic translation initiation factor5A isoform B eIF4D, Eukaryotic translation initiation factor 5A 1, EIF5A, EIF-5A, Eukaryotic translation initiation factor5A1, MGC104255., uORF A, eIF4D, Eukaryotic initiation factor 5A, Rev binding factor, EIF 5A, MGC99547, eIF 5A1, eIF5AI, Eukaryotic translation initiation factor 5A isoform B eIF 4D, eIF5A1, Eukaryotic initiation factor5A
Cellular Localization: Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions.
CAS NO: 844499-71-4
Product: NVP-BKM120
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen: Recombinant human EIF5A (1-154aa) purified from E. coli
Antigen Species: Human
Species Reactivity: Human, Mouse
Conjugation: Unconjugated
Storage Buffer: In Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide
Storage Instruction: Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20573913?dopt=Abstract
