Product Name: ELK1 antibody
Applications: IHC-P, WB
Predicted Target Size:
Positive Controls: E. Coli expressed Elk1 fusion protein.
Form Supplied: Liquid
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Affinity purified with antigen.
Full Name:
Background: The transcription factor Elk1 is a component of the ternary complex that binds the serum response element (SRE) and mediates gene activity in response to serum and growth factors. Elk1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C terminus. Phosphorylation at these sites, particularly Ser383, is critical for transcriptional activation by Elk1. Elk1 appears to be a direct target of activated MAP kinase. Biochemical studies indicate that Elk1 is a good substrate for MAP kinase, the kinetics of Elk1 phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block Elk1 activation in vivo. More recent studies have shown that Elk1 (Ser383) is also a target of the Stress Activated Kinase SAPK/JNK.
Synonyms: 311040, ELK1, 2002, P19419
Cellular Localization: Nuclear
CAS NO: 149845-06-7
Product: PSI-6130
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Recombinant full length Elk1 protein (Human).
Antigen Species: Human
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: Preservative: 0.02% Thimerosal (merthiolate). Constituents: 50% Glycerol, 1% BSA, PBS.
Storage Instruction: Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: GTX47708 recognises Elk1.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/28193737?dopt=Abstract
