Product Name: ENPP1 antibody, C-term
Applications: IHC-P, WB
Predicted Target Size:
Positive Controls: The peptide used to product this antibody is available for purchase (Catalog Number:GTX89508-PEP).
Form Supplied: Liquid
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Full Name: ectonucleotide pyrophosphatase/phosphodiesterase 1
Background: Involved primarily in ATP hydrolysis at the plasma membrane. Plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. In vitro, has a broad specificity, hydrolyzing other nucleoside 5 triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3,5-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity.
Synonyms: alkaline phosphodiesterase 1, ENPP1, PC1, Ly41 antigen, plasmacell membrane glycoprotein1, alkaline phosphodiesterase1, ectonucleotide pyrophosphatase/phosphodiesterase 1, membrane component, chromosome 6, surface marker 1, NPPS, plasmacell membrane glycoprotein 1, Ly-41 antigen, ectonucleotide pyrophosphatase/phosphodiesterase1, membrane component, chromosome6, surface marker1, phosphodiesterase I/nu, ENPP1 / PC1, NPP1, ARHR2, M6S1, PC-1, PCA1, PDNP1, PC 1, Ly 41 antigen
Cellular Localization: Targeted to the basolateral membrane in polarized epithelial cells and in hepatocytes, and to matrix vesicles in osteoblasts. In bile duct cells and cancer cells, located to the apical cytoplasmic side.
CAS NO: 380843-75-4
Product: T863
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Immunogen: C-KTHLPTFSQED
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Storage Instruction: Aliquot and store at -20°C. Minimize freezing and thawing.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody is specific for ENPP1.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/26721398?dopt=Abstract
