Product Name: ENPP3 antibody [NP4D6]
Applications: FACS, ICC/IF
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification:
Full Name: ectonucleotide pyrophosphatase/phosphodiesterase 3
Background: CD203c, also known as ENPP-3, is integral membrane ectoenzyme (ectonucleotide pyrophosphatase/phosphodiesterase 3), that hydrolyses nucleotide triphosphates and thus modulates purinergic signaling. CD203c is expressed mainly on activated basophils and mast cells. CD203c is upregulated in response to IgE-receptor cross-linking and is overexpressed on neoplastic mast cells in patients with systemic mastocytosis. Measurement of its induced enhancement on the plasma membrane is useful for diagnostics of allergies.Entrez Gene: 5169
Synonyms: B10, CD203c, NPP3, PD-IBETA, PDNP3
Cellular Localization: Located to the apical surface in intestinal and kidney epithelial cells. Located to the cell surface of basophils, and to the apical plasma membrane of bile duct cells. Secreted in serum, and in lumen of epithelial cells.
CAS NO: 405169-16-6
Product: Ko 143
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen: HEK-293 cells transfected with human ENPP3.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Storage Instruction: Store at 2-8°C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: The mouse monoclonal antibody NP4D6 reacts with ENPP3, a transmembrane ectoenzyme expressed on basophils and mast cells, and overexpressed upon their activation.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/26498179?dopt=Abstract
