Product Name: E-Cadherin antibody [21E9]
Applications: IHC, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification: The IgG fraction of culture supernatant was purified by Protein G affinity chromatography
Full Name: cadherin 1, type 1, E-cadherin (epithelial)
Background: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]
Synonyms: cadherin 1, type 1, E-cadherin (epithelial) Antibody , Arc-1 Antibody , CDHE Antibody , UVO Antibody , CD324 Antibody , CDH1 Antibody , ECAD Antibody , LCAM Antibody
Cellular Localization:
CAS NO: 371935-74-9
Product: NVP-LCQ195
Host: Mouse
Clonality: Monoclonal
Isotype: IgG2
Immunogen: human recombinant E-Cadherin protein
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: PBS
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody recognizes human E-Cadherin in western blot and Elisa.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24448264?dopt=Abstract
