Product Name: E-Cadherin antibody [67A4]
Applications: IHC-Fr
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification: Tissue culture supernatant
Full Name: cadherin 1, type 1, E-cadherin (epithelial)
Background: One of the epithelial cell adhesion molecules, E Cadherin, plays an important role in the formation of cell-cell contacts in epithelia irrespective their origin form ecto-, meso- or endodermal tissue. This early adhesion event between epithelial cells is a prerequisite for the assembly of all elements of the junctional complex. Furthermore, E Cadherin plays a crucial role in the maintenance of the epithelial junctional complex and is as such an important molecule in maintaining epithelial integrity. Over 90% of the malignant tumors are carcimomas. One of the prerequisites for the release of carcinoma cells from the primary site might be a defect in intercellular adhesion mediated by the absence of E Cadherin expression. Therefore, the expression of E Cadherin might be an important parameter for the determination of the invasive potential of epithelial neoplasms, and for the transition of a benign to a malignant neoplasm.
Synonyms: Arc-1, CDHE, 137215, CDH1, P12830, UVO, 999, ECAD, E Cadherin, LCAM, Arc1, Arc 1
Cellular Localization:
CAS NO: 663619-89-4
Product: c-FMS inhibitor
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen: The immunogen is “Human thoracic duct lymphocytes” expressed full length E-Cadherin.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Tissue culture supernatant with sodium azide
Storage Instruction: Keep as concentrated solution, aliquot and store at 4°C.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody is specific for the 123 kDa E-cadherin molecule, expressed on non-neuronal epithelial cells. This antibody reacts with tumor cell lines such as breast carcinoma cells.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24463623?dopt=Abstract
