Product Name: E-Cadherin antibody [N3C2], Internal
Applications: ICC/IF, IP, WB
Predicted Target Size: 97 kDa (note) (2)
Positive Controls: 293T , PC-12 , MCF-7
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified by antigen-affinity chromatography.
Full Name: cadherin 1, type 1, E-cadherin (epithelial)
Background: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq]
Synonyms: Arc-1 antibody, CD324 antibody, CDHE antibody, ECAD antibody, LCAM antibody, UVO antibody, CDH1 antibody, epithelial cadherin antibody, “cadherin 1, E-cadherin (epithelial) antibody”, “calcium-dependent adhesion protein, epithelial antibody”, cell-CAM 120/80 antibody, uvomorulin antibody, cadherin-1 antibody, CAM 120/80 antibody, E-Cadherin antibody, “cadherin 1, type 1, E-cadherin (epithelial) antibody”
Cellular Localization: Cell junction , Cell membrane
CAS NO: 702674-56-4
Product: Varenicline (Tartrate)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Recombinant protein encompassing a sequence within the center region of human E-Cadherin. The exact sequence is proprietary.
Antigen Species: Human
Species Reactivity: Human, Rat
Conjugation: Unconjugated
Storage Buffer: 1XPBS, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24631403?dopt=Abstract
