Product Name: Endothelin A receptor antibody
Applications: IHC-P
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Immunogen affinity purified.
Full Name:
Background: The ETA receptor is an Endothelin Receptor that mediates the effects of endothelin-1, a mitogen with potent contractile properties. In the human fetal olfactory epithelium cell line FNC-B4, the ETA receptor increases the secretion of gonadotropin-releasing hormone. Increased ETA concentration may be correlated with smooth muscle hypertrophy observed in patients suffering from bladder-outlet obstruction. ETA receptor has been reported in a variety of tissues including placenta, uterus, testis, heart, adrenal gland, lung, kidney, ovary, skin, liver, bladder, large blood vessels, cerebellum, neurons, and meningioma tumor cells. A splice variant has been identified in melanoma (Zhang et al., 1998). ESTs have been isolated from libraries from the above-mentioned tissues.
Synonyms:
Cellular Localization:
CAS NO: 252916-29-3
Product: GSK256066
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Synthetic peptide – KLH conjugated
Antigen Species:
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Phosphate buffered saline, pH 7.4 containing 0.01% sodium azide
Storage Instruction: Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27364742?dopt=Abstract
