Product Name: EpCAM antibody [EGP40/826]
Applications: ICC/IF, IHC-P
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification: Ab purified from Bioreactor Concentrate by Protein A/G
Full Name: epithelial cell adhesion molecule
Background: This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]
Synonyms: M4S1 Antibody , EGP2 Antibody , EPCAM Antibody , EGP314 Antibody , MK1 Antibody , KS1/4 Antibody , DIAR5 Antibody , MIC18 Antibody , TROP1 Antibody , EGP40 Antibody , KSA Antibody , TACSTD1 Antibody , HNPCC8 Antibody , ESA Antibody , epithelial cell adhesion molecule Antibody
Cellular Localization:
CAS NO: 410528-02-8
Product: Pracinostat
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen: A synthetic peptide (around aa 20-60) from the N-terminus of human TACSTD1 protein
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.
Storage Instruction: Antibody with azide – store at 2 to 8°C. Antibody without azide – store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: Recognizes a 40-43kDa transmembrane epithelial glycoprotein, identified as epithelial specific antigen (ESA), or epithelial cellular adhesion molecule (Ep-CAM). Ep-CAM is expressed on baso-lateral cell surface in most simple epithelia and a vast majority of carcinomas. This antibody has been used to distinguish adenocarcinoma from pleural mesothelioma and hepatocellular carcinoma. It is also useful in distinguishing serous carcinomas of the ovary from mesothelioma. This epithelial antigen plays an important role as a tumor-cell marker in lymph nodes from patients with esophageal carcinoma otherwise classified as node-negative. Epithelial antigen has also been suggested as a discriminator between basal cell and baso-squamous carcinomas, and squamous cell carcinoma of the skin.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/23784083?dopt=Abstract
