Product Name: EpCAM antibody [SPM528]
Applications: IHC-P
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification: Ab purified from Bioreactor Concentrate by Protein A/G
Full Name: epithelial cell adhesion molecule
Background: This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]
Synonyms: epithelial cell adhesion molecule Antibody , KSA Antibody , ESA Antibody , TACSTD1 Antibody , HNPCC8 Antibody , TROP1 Antibody , EGP40 Antibody , DIAR5 Antibody , MIC18 Antibody , KS1/4 Antibody , MK1 Antibody , EGP314 Antibody , M4S1 Antibody , EPCAM Antibody , EGP2 Antibody
Cellular Localization:
CAS NO: 1194044-20-6
Product: B-HT 920
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen: Neuraminidase treated GLS-1 human small cell lung carcinoma cells
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.
Storage Instruction: Antibody with azide – store at 2 to 8�C. Antibody without azide – store at -20 to -80�C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: Binding epitope of this antibody is located in the first EGF-like repeat domain (EGF1) between amino acids 27-59 of Ep-CAM. EGP40 is a 40-43kDa transmembrane epithelial glycoprotein, also identified as epithelial specific antigen (ESA), or epithelial cellular adhesion molecule (Ep-CAM). It is expressed on baso-lateral cell surface in most simple epithelia and a vast majority of carcinomas. This antibody has been used to distinguish adenocarcinoma from pleural mesothelioma and hepatocellular carcinoma. This antibody is also useful in distinguishing serous carcinomas of the ovary from mesothelioma.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22079997?dopt=Abstract
