Product Name: ITPK1 antibody [N3C3]
Applications: ICC/IF, WB
Predicted Target Size: 46 kDa (note) (3)
Positive Controls: 293T , A431 , H1299 , HeLaS3 , HepG2 , Molt-4 , Raji , mouse brain
Form Supplied: Liquid
Concentration: 0.53 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified by antigen-affinity chromatography.
Full Name: inositol 1,3,4-triphosphate 5/6 kinase
Background: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetraphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.
Synonyms: ITRPK1 antibody, ITPK1 antibody, “inositol 1,3,4-triphosphate 5/6 kinase antibody”, inositol-tetrakisphosphate 1-kinase antibody, “inositol 1,3,4-trisphosphate 5/6-kinase antibody”, “inositol 1,3,4-trisphosphate 5/6 kinase antibody”, “ins(1,3,4)P(3) 5/6-kinase antibody”, inositol-triphosphate 5/6-kinase antibody
Cellular Localization:
CAS NO: 1373422-53-7
Product: Gemifloxacin (mesylate)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Recombinant protein encompassing a sequence within the center region of human ITPK1. The exact sequence is proprietary.
Antigen Species:
Species Reactivity: Human, Mouse
Conjugation: Unconjugated
Storage Buffer: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20719964?dopt=Abstract
