Product Name: JAK1 antibody [7G6]
Applications: IHC-P
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Full Name: Janus kinase 1
Background: Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq, Jul 2008]
Synonyms: Janus kinase 1 Antibody , JAK1B Antibody , JTK3 Antibody , JAK1A Antibody
Cellular Localization:
CAS NO: 1218942-37-0
Product: Imidazolidinyl urea
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen: Synthetic Peptide of JAK1
Antigen Species: Human
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instruction: Store at -20°C. Avoid repeated freeze/thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: JAK1 Mouse Monoclonal Antibody (7G6) detects endogenous levels of JAK1
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/17891176?dopt=Abstract
