Product Name: JAM-A antibody [M.Ab.F11]
Applications: FACS, ICC/IF, IP, WB, Functional Assay
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified IgG
Full Name: F11 receptor
Background: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5 alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]
Synonyms: JAM Antibody , PAM-1 Antibody , JAM1 Antibody , JAMA Antibody , JCAM Antibody , KAT Antibody , F11R Antibody , CD321 Antibody
Cellular Localization:
CAS NO: 174634-09-4
Product: Acetylleucine
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen: Human platelet membranes
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: PBS, 0.09% Sodium Azide
Storage Instruction: Keep as concentrated solution. For short-term storage, store at 4° C (up to 10 days). For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. This product may contain precipitation. Recommend microcentrifugation before use.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody has been shown to activate platelets, leading to aggregation and granule secretion.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/15794746?dopt=Abstract
