Product Name: JNK1 antibody [2F10]
Applications: WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification: Protein A/G purified
Full Name: mitogen-activated protein kinase 8
Background: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells (By similarity). Phosphorylates heat shock factor protein 4 (HSF4). JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.
Synonyms: PRKM8, JNK1A2, MAPK8, JNK21B1/2, SAPK1, JNK1, JNK
Cellular Localization:
CAS NO: 478336-92-4
Product: Methicillin (sodium salt)
Host: Mouse
Clonality: Monoclonal
Isotype: IgG2a
Immunogen: Recombinant protein expressed in E.coli corresponding to amino acids 1-384 of human JNK1
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Storage Instruction: For short-term storage, store at 4°C or aliquot into working amounts and store at -20°C. For long-term storage, store at -70°C (aliquotted). Avoid repeated freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: GTX84142 is specific for amino acids 1-384 of human JNK1
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24807903?dopt=Abstract
