Product Name: JNK (phospho Tyr185) antibody
Applications: IHC, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Antigen affinity purification
Full Name: mitogen-activated protein kinase 8
Background: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Synonyms: SAPK/JNK (phospho Tyr185) (pY185) Antibody, phospho SAPK/JNK (phospho Tyr185) (Tyr185) Antibody, SAPK/JNK (phospho Tyr185) Tyr185 Phospho Antibody, Phospho SAPK/JNK (phospho Tyr185) Tyr185 Antibody, SAPK/JNK (phospho Tyr185) Y185 Phospho Antibody, Phospho
Cellular Localization:
CAS NO: 834903-43-4
Product: Phenazopyridine (hydrochloride)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: A synthesized peptide derived from human SAPK/JNK around the phosphorylation site of Tyr185
Antigen Species: Human
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24627473?dopt=Abstract
