Product Name: JunB antibody
Applications: IP, WB, ChIP assay
Predicted Target Size:
Positive Controls:
Form Supplied: Lyophilized powder
Concentration: 3 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified
Full Name: Jun-B oncogene
Background: Cellular oncogenes, or proto-oncogenes, play pivotal roles in cellular communication pathways that regulate normal growth, development and differentiation. The cellular oncogene families fos and jun encode nuclear proteins that can function as transcription factors. The fos family of nuclear oncogenes encode cFos, FosB, (fos-related antigen) Fra1, and Fra2. Fos and Jun dimerize to form Activator Protein-1 (AP-1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13-acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the ‘leucine-zipper’ motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP-1 dependent genes.
Synonyms: Junb, Jun-B oncogene
Cellular Localization:
CAS NO: 928672-86-0
Product: Clofazimine
Host: Rabbit
Clonality: Polyclonal
Isotype:
Immunogen: Synthetic peptide corresponding to residues D(45) P Y R G L K G P G A R G P G P E(61) of mouse JunB.
Antigen Species: Mouse
Species Reactivity: Mouse
Conjugation: Unconjugated
Storage Buffer: lyophilized, purified rabbit IgG. Reconstitute with PBS.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24123685?dopt=Abstract
