Product Name: KCNN3 antibody
Applications: ICC/IF, IHC, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification: Affinity purified on immobilized antigen.
Full Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
Background: Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Synonyms: hSK3 Antibody , SK3 Antibody , potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 Antibody , SKCA3 Antibody , KCa2.3 Antibody , KCNN3 Antibody
Cellular Localization:
CAS NO: 83777-30-4
Product: Econazole
Host: Rabbit
Clonality: Polyclonal
Isotype:
Immunogen: Peptide DTSGHFHDSGVGDLDEDPKC, corresponding to amino acid residues 2-21 of human KCNN3 (SK3) (Accession Q9UGI6). Intracellular, N-terminus.
Antigen Species: Human
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: Phosphate buffered saline (PBS), pH 7.4, 1% BSA and 0.05% NaN3.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/25237204?dopt=Abstract
